Measuring working memory load effects on electrophysiological markers of attention orienting during a simulated drive

Intersection accidents result in a significant proportion of road fatalities, and attention allocation likely plays a role. Attention allocation may depend on (limited) working memory (WM) capacity. Driving is often combined with tasks increasing WM load, consequently impairing attention orienting. This study (n = 22) investigated WM load effects on event-related potentials (ERPs) related to attention orienting. A simulated driving environment allowed continuous lane-keeping measurement. Participants were asked to orient attention covertly towards the side indicated by an arrow, and to respond only to moving cars appearing on the attended side by pressing a button. WM load was manipulated using a concurrent memory task. ERPs showed typical attentional modulation (cue: contralateral negativity, LDAP; car: N1, P1, SN and P3) under low and high load conditions. With increased WM load, lane-keeping performance improved, while dual task performance degraded (memory task: increased error rate; orienting task: increased false alarms, smaller P3). Practitioner Summary: Intersection driver-support systems aim to improve traffic safety and flow. However, in-vehicle systems induce WM load, increasing the tendency to yield. Traffic flow reduces if drivers stop at inappropriate times, reducing the effectiveness of systems. Consequently, driver-support systems could include WM load measurement during driving in the development phase

Exploring the Driving Behavior of Youth with an Autism Spectrum Disorder: A Driver Instructor Questionnaire

Youth with an autism spectrum disorder (ASD) depend to a great extent on friends and family for their transportation needs. Although little research exists, Cox et al. (2012) surveyed parents/caregivers of youth with ASD (previously) attempting to learn to drive. This study serves as an extension by surveying driver instructors. Several questions queried advice for teaching youth with ASD how to drive, and for improving the current driving education to better fit the needs of youth with ASD. Furthermore, respondents were asked to indicate whether specific characteristics, often associated with ASD, have an impact on driving ability. A total of 52 driver instructors reported potential problems when teaching youth with ASD to drive. Advice for teaching youth with ASD to drive mainly focused on a need for structure, clarity, visual demonstration, practice, repetition and an individualized approach. Results however also showed that the relation between ASD and driving performance might not always be negative but can be positive. Practical implications are provided

Dynamic travel information strategies in advance traveler information systems and their effect on route choices along highways

Advance Traveler Information Systems (ATIS) inform drivers about traffic incidences and expected travel times/ delays en-route. An online computer study was conducted in Qatar to investigate drivers' willingness to divert to an alternative route given changes in expected travel conditions. Respondents’ route choices were queried after exposure for 6 seconds to varying display strategies. The results from a binary logistic regression and a stated preference survey showed that delay times and displayed colors on a Graphical Route Information Panel (GRIP) effectively influence drivers to take the alternative route, while total travel times were preferred for Variable Message Signs (VMS)

A study on the determinants of Ethiopian minibus taxi drivers' speeding behaviour: An application of the 'major theorists' model

Speeding is the most common road safety problem that results in many traffic accidents in Addis Ababa, Ethiopia. Minibus taxis substantially contribute to speed-related road traffic crashes in Addis Ababa. This study aimed to investigate minibus taxi drivers' speeding behaviour using the 'major theorists' model, an integrated framework drawn from five dominant motivational models. Participants were 218 Ethiopian male minibus taxi drivers in Addis Ababa. The study followed a three-step sequential procedures: 1. Development of a new instrument addressing the assumptions of the 'major theorists' model, and validation using Principal Component Analysis (PCA). 2. Exploration of associations between variables in the 'major theorist' model using a Pearson's correlation analysis. 3. Identification of statistically significant predictors of self-reported speeding via linear multiple regression analyses. It was found that self-efficacy to drive fast, weak speed enforcement, social pressure from relatives to drive fast, and behavioural intention to drive fast were significant predictors of self-reported speeding behaviour. These findings can be applied in awareness rising interventions for taxi driver to improve their speed limit compliance.The NPRP award [NPRP11S-1228-170143] from the Qatar National Research Fund (a member of Qatar Foundation)

Clinical use of lithium salts: guide for users and prescribers

Lithium has been used clinically for 70 years, mainly to treat bipolar disorder. Competing treatments and exaggerated impressions about complexity and risks of lithium treatment have led to its declining use in some countries, encouraging this update about its safe clinical use. We conducted a nonsystematic review of recent research reports and developed consensus among international experts on the use of lithium to treat major mood disorders, aiming for a simple but authoritative guide for patients and prescribers

A multidisciplinary approach for generating globally consistent data on mesophotic, deep-pelagic, and bathyal biological communities

Approaches to measuring marine biological parameters remain almost as diverse as the researchers who measure them. However, understanding the patterns of diversity in ocean life over different temporal and geographic scales requires consistent data and information on the potential environmental drivers. As a group of marine scientists from different disciplines, we suggest a formalized, consistent framework of 20 biological, chemical, physical, and socioeconomic parameters that we consider the most important for describing environmental and biological variability. We call our proposed framework the General Ocean Survey and Sampling Iterative Protocol (GOSSIP). We hope that this framework will establish a consistent approach to data collection, enabling further collaboration between marine scientists from different disciplines to advance knowledge of the ocean (deep-sea and mesophotic coral ecosystems)

Thyroid Hormone Signalling Genes Are Regulated by Photoperiod in the Hypothalamus of F344 Rats

Seasonal animals adapt their physiology and behaviour in anticipation of climate change to optimise survival of their offspring. Intra-hypothalamic thyroid hormone signalling plays an important role in seasonal responses in mammals and birds. In the F344 rat, photoperiod stimulates profound changes in food intake, body weight and reproductive status. Previous investigations of the F344 rat have suggested a role for thyroid hormone metabolism, but have only considered Dio2 expression, which was elevated in long day photoperiods. Microarray analysis was used to identify time-dependent changes in photoperiod responsive genes, which may underlie the photoperiod-dependent phenotypes of the juvenile F344 rat. The most significant changes are those related to thyroid hormone metabolism and transport. Using photoperiod manipulations and melatonin injections into long day photoperiod (LD) rats to mimic short day (SD), we show photoinduction and photosuppression gene expression profiles and melatonin responsiveness of genes by in situ hybridization; TSHβ, CGA, Dio2 and Oatp1c1 genes were all elevated in LD whilst in SD, Dio3 and MCT-8 mRNA were increased. NPY was elevated in SD whilst GALP increased in LD. The photoinduction and photosuppression profiles for GALP were compared to that of GHRH with GALP expression following GHRH temporally. We also reveal gene sets involved in photoperiodic responses, including retinoic acid and Wnt/ß-catenin signalling. This study extends our knowledge of hypothalamic regulation by photoperiod, by revealing large temporal changes in expression of thyroid hormone signalling genes following photoperiod switch. Surprisingly, large changes in hypothalamic thyroid hormone levels or TRH expression were not detected. Expression of NPY and GALP, two genes known to regulate GHRH, were also changed by photoperiod. Whether these genes could provide links between thyroid hormone signalling and the regulation of the growth axis remains to be investigated